At CYTOO, we reproduce this phenomenon on our MyoScreen plates through micropatterning, and we’ve turned it into a powerful screening tool:
→ Quantifiable dose-dependent response to agrin
→ Compatible with motor neuron/myotube co-cultures
→ Innovative data science approach with 4 complemantary readouts: AChR intensity, cluster area, coverage, count per myotube
The result: an in vitro model that captures the complexity of the interactions between neurons and skeletal muscle in a high-throughput screening-compatible format to support to innovation on devastating disease such as SMA.
If you’re working on neuromuscular diseases, gene therapy, or NMJ-targeting drug development – let’s talk 👉🏻 contact@cytoo.com
