🔬 Autophagy in Skeletal Muscle: Detect it. Quantify it. Target it.

février 10, 2026

Autophagy is a critical quality-control mechanism that clears damaged proteins and organelles from muscle cells. Autophagy dysregulation plays a role in disease pathogenesis — yet its accurate detection remains technically challenging.

Our MyoScreen platform addresses this gap.

Through advanced fluorescence microscopy and high-content analysis of individual myotubes, we enable:

✔️ Sensitive visualization of LC3B-positive autophagosomes

✔️ Precise identification of LC3B/LAMP1 co-labelled autolysosomes

✔️ Robust quantification of autophagic flux

✔️ Simultaneous assessment of myotube size, differentiation & viability

This integrated approach supports high-throughput screening for compounds that modulate autophagy — whether the goal is to enhance it (e.g., myofibrillar myopathies) or inhibit it (e.g., Pompe disease).

📊 See image: Chloroquine treatment reveals dose-dependent accumulation of autophagic compartments, readily quantified by MyoScreen.