Metabolic disorders
Multiple pathways. A mounting burden on skeletal muscle. Metabolic disorders such as type 2 diabetes, sarcopenia, obesity, and cachexia share a devastating common ground: the progressive deterioration of skeletal muscle function.
CYTOO’s MyoScreen™ platform recapitulates the key hallmarks of metabolic muscle dysfunction in micropatterned primary human myotubes. It enables sensitive, high-content evaluation of therapeutic candidates from small molecules and siRNAs to metabolites, across readouts spanning lipid accumulation, mitochondrial network dynamics, glucose uptake, and functional muscle integrity among others.
CYTOO's approach
At CYTOO, our MyoScreen™ platform leverages physiologically relevant micropatterned skeletal muscle cultures derived from human primary donor cells to model key cellular and functional features of metabolic muscle disorders, including type 2 diabetes, sarcopenia, obesity, and cachexia.
Using this system, high-content imaging combined with AI-driven analysis enables sensitive detection of key metabolic readouts including lipid accumulation and mitochondrial network dynamics. Associated structural and functional muscle phenotypes are also captured. All these readouts are assessed across disease-relevant culture conditions, modulated by nutrients, fatty acids, and pro-inflammatory cytokines, as well as therapeutic candidates.
These multiparametric readouts support the evaluation of therapeutic strategies targeting the multiple mechanisms underlying metabolic muscle dysfunction.
Overall, CYTOO’s technologies provide an integrated, end-to-end platform supporting metabolic disorder drug development.
About Metabolic disorders
Metabolic disorders such as type 2 diabetes, sarcopenia, and cachexia represent a major and growing global health challenge. A common feature across these conditions is their detrimental impact on skeletal muscle through various mechanisms including impaired glucose metabolism, lipid accumulation, chronic inflammation, and mitochondrial dysfunction. These processes all contribute to progressive muscle loss with associated structural and functional decline. Our platform offers dedicated assays and readouts to evaluate the effect of therapeutic candidates on skeletal muscle in relevant metabolic models.
Explore our catalog of readouts
How can we work together
Everything is tailored to your needs through a flexible R&D partnership model that fosters true collaboration and innovation. We offer adaptable project structures and FTE allocation to fit your goals.