Lead Profiling & Mechanism of Action

Our expertise

CYTOO characterizes and differentiates lead candidates by assessing their efficacy, specificity, and mechanism of action in physiologically relevant skeletal muscle models. This generates functional data that supports candidate selection and de-risking of development programs.

Our approach

We profile lead candidates across multiple donors and assays to evaluate the consistency and robustness of response.

By combining high-content imaging, quantitative morphological and functional assays, and transcriptomic analyses, we investigate compound effects at both the cellular and molecular levels.

Mechanistic studies include dose-response profiling, time-course experiments, and target/pathway modulation using pharmacological and genetic tools.

This integrative approach delivers in-depth insights into compound activity, supporting rational lead selection and optimization.

A comprehensive library of functional assays to dissect mechanisms of action

We offer a growing library of quantitative and functional assays to characterize drug activity across key biological processes in skeletal muscle. This enables detailed mechanism-of-action profiling and candidate differentiation.

Our deep expertise in muscle biology, combined with our advanced technological platform and integrated data science workflows, allows us to design and implement custom assays tailored to partner-specific needs.

How can we work together

Everything is tailored to your needs through a flexible R&D partnership model that fosters true collaboration and innovation. We offer adaptable project structures and FTE allocation to fit your goals.

In cases of joint development, outlicensing opportunities are also available for our MyoScreen™ technology, including assays and customised image analysis scripts.