3 Bethesda MetroCenter
Bethesda, MD 20814
Phone: (001) 301 525 5262
Based on cardio-specific micropatterns, we have reconstituted a more physiological environment and a higher level of maturation of human iPS- derived cardiomyocytes that can be organized and connected to reconstitute cardiac fibers. In such context, cardiomyocytes present a better sarcomere alignment, an increase in Connexin 43 expression and synchronous cell beating. Taking advantage of these important features, we are setting up hypertrophy, Ca2+ flux and cell beating assays.
Cardiotoxicity, electrophysiology, beating, hypertrophy, contractility, fibrosis
Standardized morphology, robustness, HCA compatibility, synchronized beating
Our cardiomyocyte cellular model can be in-licensed should you wish to further develop novel HCA compatible read-outs and assays. CYTOO also offers custom cellular model and cell-based assay development through research contracts.
We also offer a fee-for service should you wish to screen your compounds for cardiac toxicity (Ca2+ flux, cell beating, contractility, hypertrophy, fibrosis).