The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton.

J. Biol. Chem. 2011;286(30):26743–26753.

  • Lombardi ML
  • Jaalouk DE
  • Shanahan CM
  • Burke B
  • Roux KJ
  • Lammerding J.
Link: 
http://www.jbc.org/content/286/30/26743.long

Keywords:

  • cell line
  • cytoskeleton
  • mechanotransduction
  • nuclear envelope
  • nucleo-cytoskeletal coupling
  • force transmission
  • LINC (Linker of Nucleoskeleton and Cytoskeleton) complex
  • intracellular forces
  • nuclear positioning
  • cell polarization
  • muscular dystrophies
  • cardiomyopathies
  • crossbow-shaped micropatterns

Application: