MyoScreen™: Human myotubes derived from primary myoblasts

 
 

CYTOO has developed a first-in-class myotube model by fully maturing human primary myoblasts. Myotubes show a high level of striation, high fusion index with aligned nuclei, and low morphological variability enabling high Z’ factor and HCS screening. 

 

 

 

 

Accelerated differentiation of Myoblasts

 

 

 

Myotube formation is greater and faster on CYTOO compared to conventional culture

 

 

 

 

 

Myotube maturation

Myotube Maturation

 

 

Sarcomeric striation is drastically increased on CYTOO substrates compared to conventional condition.

 

 

 

Guiding myogenesis decreases myotube variability​

 

 

 

More mature phenotype, high level of striation, aligned nuclei, in-vivo like and standardized morphology

 

 

Neuromuscular junction functionalization

Contractility

 

Applications

‒Drug discovery: 
•Muscle wasting (sarcopenia, cachexia, muscle disuse)
•Metabolism
‒Disease models
•Muscular diseases incl. myopathies
•Neuromuscular disorders
•Metabolic disorders
•Muscle fibrosis
‒Myotoxicity
‒Animal health
•Increase muscle mass
‒Dermis contractility
 

Download our poster here

Our myotube cellular model can be in-licensed should you wish to further develop novel HCA compatible read-outs and assays. CYTOO also offers custom cellular model and cell-based assay development through research contracts.

For more information on our cellular models and Cell-Based Assays, please contact us. For business options and terms, click here.